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亂挊彂亃
| 儗乕僯儞僕儍乕
偺怴惗壔妛乮戞5斉乯乽忋乿丆淎愳彂揦乮2010乯乮東栿暘扴乯 |
| 怘暔壢妛奣榑丆揑応婸壚曇丆挬憅彂揦 乮2003乯 |
| 惗壔妛丂婎慴偺婎慴丆壔妛摨恖乮2002乯 |
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| 峺慺僴儞僪僽僢僋乮戞3斉乯丆挬憅彂揦, 2008 |
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亂庴徿楌亃
- Rockefeller Foundation Fellowship (1984)
- Rockefeller Foundation Research Grant (1986) "Interaction of gossypol
with proteins from Spisula and bull sperms"
- Travel Award to International Congress on Chemical and Biological Aspects
of Vitamin B6 Catalysis, Turku, Finland (1987)
- Rockefeller Foundation Research Grant (1988) "Chemical studies on gossypol
with macromolecules from sperms, parasites, and viruses"
- Juvenile Diabetes Foundation International Research Grant (1989) "Nonenzymic
glycation of proteins"
- New York Heart Association Molly Berns Memorial Investigatorship Award
(1989)
- American Heart Association Research Grant (1990) "Chemical and genetic
engineering of hemoglobin functions"
- Rockefeller Foundation Research Grant (1990) "Gossypol action on Spisula
sperm"
- 埉徤巕嵿抍彠椼徿 (1992)丂
- 嶰搰奀塤婰擮嵿抍尋媶彆惉 (1992)丂乽弶婜儊僀儔乕僪斀墳偵偍偗傞惗壔妛揑傾僾儘乕僠乿
- 擔杮惈嫵堢嫤夛尋媶彆惉
(1992)丂乽惛巕塣摦慾奞嵻媦傃峈僄僀僘丒僂僀儖僗嵻偱偁傞僑僔億乕儖偺惗壔妛揑尋媶亅婎慴壢妛尋媶椞堟傛傝偺惈嫵堢傊偺傾僺乕儖乿
- 擔杮惗壔妛夛JB榑暥徿 (1995) "Identification of active site lysyl residues of
phenylalanine dehydrogenase by chemical modification with methyl acetyl
phosphate combined with site-directed mutagenesis"
- 嫗搒戝妛屻墖夛彆惉 (1996)
- 僒儞僩儕乕乮姅乯尋媶彆惉 (2000)丂乽挻椪奅棳懱拞偱偺旝惗暔斀墳乿
- 塝忋怘昳丒怘暥壔怳嫽嵿抍尋媶彆惉 (2000)丂乽崄恏椏偼恄宱揱払暔幙崌惉峺慺傪巋寖偡傞偐丠乿
- 拞擶尋媶彠椼夛尋媶彆惉乮2001乯
乽峺曣偺GABA崌惉峺慺僌儖僞儈儞巁僨僇儖儃僉僔儔乕僛偺婡擻夝愅偍傛傃崅敪尰宆峺曣偺扵嶕乿
- 婙塭夛尋媶彆惉乮2001乯乽怘昳傾儗儖僊乕偲僸僗僞儈儞崌惉峺慺偺尋媶乿
- 偆傑枴尋媶夛尋媶彆惉乮2005-2006乯乽枴錛偵偍偗傞GABA崌惉峺慺偺枴妎傊偺娭梌傪峫偊傞乿
- 乮撈乯壢妛媄弍怳嫽婡峔
抧堟僀僲儀乕僔儑儞憂弌憤崌巟墖帠嬈廳揰抧堟尋媶奐敪悇恑僾儘僌儔儉 暯惉18擭搙乽僔乕僘敪孈帋尡乿
乽揤慠暔桼棃偺僸僗僞儈儞崌惉峺慺慾奞嵻偺扵嶕傛傝怴婯峈僸僗僞儈儞栻偺奐敪尋媶乿
- 偆傑枴尋媶夛尋媶彆惉乮2007-2008乯乽枴錛嵶朎撪偺僞儞僷僋幙暋崌懱宍惉偺扵嶕偲枴妎忣曬揱払偵娭梌偡傞僞儞僷僋幙偺儅僢僺儞僌乿
- 擔杮枴偲擋妛夛 2007擭搙榑暥徿 "GABA is produced in taste bud"
- 擔杮枴偲擋妛夛 2008擭搙榑暥徿 乽GABA偺枴妎僥僗僩偵傛傞枴姶妎傊偺娭梌偲崄恏椏惉暘偵傛傞GABA崌惉峺慺偺妶惈惂屼偵偮偄偰乿
- 偆傑枴尋媶夛尋媶彆惉乮2008-2009乯乽偍偄偟偝傪偦偙側傢偢尭墫偵摥偒偐偗傞怘昳惉暘偺扵媮偵偮偄偰乣GABA崌惉峺慺偺妶惈惂屼偵娭傢傞怘昳惉暘偐傜偺傾僾儘乕僠乣乿乮暘扴乯
- 擔杮枴偲擋妛夛 2009擭搙榑暥徿 乽枴嵶朎偺嵶朎宆偲墳摎摿惈乿
- 擔杮擾寍壔妛夛 戞7夞擾寍壔妛尋媶婇夋徿丗 乮廳揰尋媶椞堟嘇乽婡擻惈怘昳慺嵽偍傛傃怘昳乿乯乽尭墫怘昳奐敪傪栚巜偟偰丗揤慠暔桼棃惉暘偺墫枴憹嫮岠壥傪掕検揑偵昡壙偡傞僔僗僥儉奐敪乿
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亂尨挊榑暥亃
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Purification of L-glutamate
decarboxylase from rat brain.Ann. Reports Grad. Sch. Human. & Sci., 23, 255-264 (2008)
|
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Effects of food components on the activity of GABA synthetic enzyme. Ann. Reports Grad. Sch. Human. & Sci., 23, 309-317 (2008)
|
|
枴錛嵶朎偵偍偗傞GABA崌惉亅僌儖僞儈儞巁偺嫙媼偲GABA偺棙梡亅丆價僞儈儞, 82, 387-394 (2008)
|
|
Purification of L-glutamate
decarboxylase from monkey brain. Biosci. Biotech. Biochem., 72, 2269-2276 (2008)
|
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Inhibitory activity of Pimenta dioica extracts and constituents on recombinant
human histidine decarboxylase. Food Chem., 113, 445-449 (2009)
|
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壛岺嵪傒愒恎嫑拞偵娷傑傟傞僸僗僞儈儞偺専弌朄偺専摙丆擔杮壠惌妛夛帍丆59, 923-927 (2008)
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崓嬠偵傛傞拑梩偺掓枴夵慞丆擔杮壠惌妛夛帍丆59, 999-1004 (2008)
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僸僩桼棃僸僗僠僕儞僨僇儖儃僉僔儔乕僛妶惈傪慾奞偡傞栻梡怉暔偺僗僋儕乕僯儞僌丆擔杮壠惌妛夛帍丆59,
1011-1016 (2008)
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枴嵶朎偺嵶朎宆偲墳摎摿惈丆擔杮枴偲擋妛夛帍丆15丆285-288 (2008)
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僌儖僞儈儞巁僨僇儖儃僉僔儔乕僛乮GAD乯傪敪尰偡傞枴錛嵶朎偵偍偗傞僌儖僞儈儞巁庢傝崬傒偺壜擻惈偲GABA偺摦岦偵偮偄偰丆擔杮枴偲擋妛夛帍丆15丆325-328 (2008)
|
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儅僂僗II宆枴嵶朎偺敪壩昿搙埶懚惈ATP曻弌丆擔杮枴偲擋妛夛帍丆15丆381-384 (2008)
|
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Expression of
glutamate decarboxylase isoform, GAD65, in human mononuclear leukocytes: A
possible implication of C-terminal end deletion by Western blot and RT-PCR
study. J. Biochem., 142, 633-638 (2007)
|
|
Cells expressing GABA synthetic enzyme, glutamate decarboxylase, in stomach
and intestine: RT-PCR and immunohistochemistry studies. J. Biol. Macromol., 7, 55-62 (2007)
|
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Analysis of
intron-exon positioning on glutamate decarboxylase and its relation with
evolution. J.
Biol. Macromol., 7, 35-48 (2007)
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僸僗僠僕儞僨僇儖儃僉僔儔乕僛妶惈偵媦傏偡崄恏椏拪弌暔偺慾奞岠壥偺専摙丆擔杮壠惌妛夛帍丆58, 17-22 (2007).
|
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Food components inhibiting recombinant human histidine decarboxylase activity.
J. Agr. Food Chem. 55, 299-304 (2007).
|
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GABA-synthesizing enzyme, GAD67, from dermal fibroblasts:
Evidence for a new skin function. Biochim. Biophys. Acta, 1770, 291-296 (2007).
|
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GABA is produced in taste bud. Chem. Senses, 32, J19 (2007), also 擔杮枴偲擋妛夛帍丆13, 547-550 (2006)
|
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Bioinformatic study on histidine decarboxylase. J. Biol. Macromol., 6, 11-27
(2006).
|
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姱擻専嵏偵傛傞GABA偺歯岲揑懁柺偺専摙, 撧椙彈巕戝妛壠惌妛尋媶丆53, 1-6 (2006).
|
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Resonance
assignments for the DNA binding domain of XPF-ERCC-1
heterodimer. J. Biomol. NMR, 32, 175 (2005).
|
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Putative cis-elements in the promoter region of
the carrot phenylalanine ammonia-lyase gene induced during anthocyanin
synthesis. J.
Plant Res., 116, 155-159
(2003).
|
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Immunohistochemical study of the
localization of glutamate decarboxylase in rodent's submandibular gland. J.
Biol. Macromol., 2, 76-77 (2002).
|
|
Sub-zero temperature inactivation of
carboxypeptidase Y under high hydrostatic pressure. Eur. J. Biochem.,
269,
4666-4674 (2002).
|
|
Replacement of His12 or His119 of bovine
pancreatic ribonuclease A with acidic amino acid residues for the modification
of activity and stability. J. Biosci. Bioeng., 94, 39-44
(2002).
|
|
Amphipathic property of free sulfhydryl
group contributes to an increase in the catalytic efficiency of carboxypeptidase
Y. Eur.
J. Biochem., 269, 3220-3225 (2002).
|
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Increased proteolytic susceptibility of
carboxypeptidase Y caused by modification of the disulfide zipper. Biosci.
Biotechnol. Biochem., 66, 1393-1395
(2002).
|
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Significance of the four carboxyl
terminal amino acid residues of bovine pancreatic ribonuclease A for structural
folding. J. Biochem., 131, 193-200 (2002).
|
|
Gene cloning and characterization of
alanine racemases from Shigella dysenteriae, Shigella boydii,
Shigella flexneri, and Shigella sonnei. Biochem. Biophys. Res.
Commun., 288, 676-684 (2001).
|
|
Substrate recognition mechanism of
carboxypeptidase Y. Biosci. Biotechnol. Biochem.,
65, 2465-2471 (2001).
|
|
Microanalysis
of GABA: An application for evaluating GABA
production in yeast strains and the effect of spice extracts on glutamate decarboxylase activity. J. Biol.
Macromol., 1, 45-48
(2001).
|
|
Structural and functional changes in bovine
pancreatic ribonuclease A by the replacement of Phe120 with other hydrophobic
residues. J. Biochem., 129, 917-922 (2001).
|
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Interaction mode of H397A mutant
carboxypeptidase Y with protein substrates analyzed by the surface plasmon resonance.
Bull. Chem.
Soc. Japan, 73, 2587-2590
(2000).
|
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Expression of functional pancreatic
ribonuclease A in yeast: Comparative expression system between Saccharomyces cerevisiae and Pichia
pastoris. Biosci.
Biotechnol. Biochem.,
64, 2437-2444 (2000).
|
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Enzymatic and structural aspects on glutamate decarboxylase.丂 J. Mol.
Catalysis B: Enzymatic, 10, 67-79 (2000).
|
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Effect of mutagenic replacement of carboxyl terminal
amino acid, Val124, on properties and regeneration of bovine pancreatic ribonuclease A.丂
J.
Biochem., 127, 877-881
(2000).
|
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Carboxypeptidase Y: Structural basis for protein sorting and catalytic triad.丂
J.
Biochem.,
126, 1-6
(1999).
|
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Contribution of the carbohydrate moiety to conformational
stability of the carboxypeptidase Y: High
pressure.丂Eur.
J. Biochem.,
262, 475-483
(1999).
|
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Role
of carbohydrate moiety in carboxypeptidase Y:
Structural study of mutant enzyme lacking carbohydrate
moiety.
Biosci.
Biotechnol. Biochem., 63, 1045-1050
(1999).
|
|
Cathepsin A and
related enzymes in eukaryote乮恀妀惗暔偵嫟捠偺僇僥僾僔儞A娭楢峺慺乯丆
惗懱偺壢妛丆50,
135-139 (1999).
|
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The single
cysteinyl residue (Cys341) of carboxypeptidase Y for cavity control in the S1
substrate binding pocket. Advances in
High Pressure Bioscience & Biotechnology (Ludwig, H., ed), Springer,
Heidelberg, pp. 267-270 (1999).
|
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Use of high
pressure to investigate the role of carbohydrate moiety in the conformational
stability of carboxypeptidase Y. Advances in
High Pressure Bioscience & Biotechnology (Ludwig, H., ed), Springer,
Heidelberg, pp. 207-210 (1999).
|
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Expression of human histidine
decarboxylase in Saccharomyces
cerevisiae.丂J. Biochem.
Mol. Biol. Biophys., 2, 141-146
(1998).
|
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Proton-relay system of carboxypeptidase Y as a sole
catalytic site: Studies on mutagenic replacement of His397.丂J.
Biochem., 124, 446-450
(1998).
|
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Role
of Phe120 on the activity and structure of bovine pancreatic ribonuclease
A.丂J.
Biochem., 124, 410-416
(1998).
|
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Bovine spleen cathepsin A:
Characterization and comparison with protective protein.丂J.
Biochem., 120, 701-706
(1998).
|
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High-pressure
effect on Cys341 substitution mutants of carboxypeptidase Y. High Pressure Biotechnology (S. Kunugi and
R. Hayashi, eds.), Sanei Shuppan, Kyoto, 29-36
(1998).丂
|
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Combined application of sub-zero temperature
and high pressure on biological materials. High
Pressure Food Science, Bioscience and Chemistry (N.S. Isaacs, ed.),
Royal Society of Chemistry, England, 166-174
(1998).丂
|
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Analysis of self-incompatibility-related ribonucleases
(S-RNases) in two species of pears, Pyrus communis and Pyrus
ussuriensis.丂Scientia
Horticulturae, 66, 159-167
(1996).
|
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A
novel heterologous gene expression system in Saccharomyces cerevisiae using the
isocitrate lyase promoter from Candida tropicalis. Appl. Microbiol. Biotechnol., 44, 759-765
(1996).
|
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A
large compressibility change of proteins induced by a
single amino acid substitution. Protein
Science, 5, 542-545 (1996).
|
埲壓敳悎
|
Identification of the
catalytic histidine residue participating in the charge-relay system of
carboxypeptidase Y.
Protein
Science, 4, 2433-2435
(1995). |
|
Identification of
active site lysyl residues of phenylalanine dehydrogenase by chemical
modification with methyl acetyl phosphate combined with site-directed
mutagenesis. J.
Biochem., 116, 1370-1376
(1994).
|
|
Inactivation of
glutamate racemase of Pediococcus pentosaceus with L-serine
O-sulfate. Biosci.
Biotech. Biochem., 57, 1978-1979
(1993).
|
|
Random chemical
modification of the oxygen-linked chloride-binding sites of hemoglobin. Those in the central dyad axis may influence the transition between deoxy-
and oxy-hemoglobin. J.
Protein Chem.,
12, 561-570
(1993).
|
|
Kinetic and
stereochemical comparison of wild-type and active-site K145Q mutant enzyme of
bacterial D-amino
acid transaminase. J. Biol.
Chem., 268, 6932-6938
(1993).
|
|
Regulation of
serotonin-induced calcium uptake in Spisula oocytes tricyclic antidepressants. Neuroscience Lett., 151, 101-103
(1993).
|
|
Effects of Methyl
acetyl phosphate, a covalent anti-sickling agent, on the density profiles of
sickle erythrocytes. J. Lab.
Clin. Med., 120, 152-158
(1992).
|
|
The functional,
oxygen-linked chloride binding sites of hemoglobin are contiguous within a channel in the central cavity. J. Protein Chem., 11, 177-185
(1992).
|
|
Substitution of
glutamine for lysine at the pyridoxal phosphate binding site of bacterial D-amino
acid transaminase: Effects of exogenous
amines on the slow formation of intermediates.
J. Biol. Chem., 265, 22306-22312
(1990).
|
|
Effects of D-serine
on bacterial D-amino
acid transaminase: Formation of a new
spectral band and inactivation of the enzyme.
Biochemistry, 28, 8798-8803
(1989).
|
|
Stereochemistry of
reactions catalyzed by bacterial D-amino
acid transaminase. J. Biol.
Chem., 264, 17784-17789
(1989).
|
|
Methyl acetyl phosphate as a covalent probe for anion
binding sites in human and bovine hemoglobins.
J. Biol. Chem., 264, 12344-12351
(1989).
|
|
Sequence-dependent
reactivity of model peptides with glyceraldehyde. Carbohydr. Res., 189, 49-63
(1989).
|
|
g-Acetylenic-g-aminobutyrate
as an enzyme-activated inhibitor of D-amino
acid transaminase. Biochimie, 71, 505-508
(1989).
|
|
Inactivation of human immunodeficiency virus in vitro by gossypol. Contraception, 39, 579-587
(1989).
|
|
Some factors that
influence the non-enzymic glycation of peptides and
polypeptides by glyceraldehyde. J. Protein
Chem., 8, 299-315
(1989).
|
|
Activity and spectroscopic properties of bacterial D-amino
acid transaminase after multiple site-directed mutagenesis of a single
tryptophan residue. Biochemistry, 28, 510-516
(1989).
|
|
Site-directed mutagenesis of the cysteinyl residues and the active site
serine residue of bacterial D-amino
acid transaminase. Biochemistry, 28, 505-509
(1989).
|
|
Properties
of carboxymethylated, cross-linked hemoglobin A. Biochemistry, 26, 5755-5761
(1987).
|
|
Inhibition
of the gelation of extracellular and intracellular hemoglobin S by selective
acetylation with methyl acetyl phosphate.
Biochemistry, 26, 3125-3129
(1987).
|
|
Pyrrolopyridine derivatives
from pyridoxal 5'-sulfate. Biochemistry, 21, 5212-5219
(1982).
|
|
Chemistry of the
inactivation of cytosolic aspartate aminotransferase by serine-O-sulfate. Biochemistry, 21, 4387-4393
(1982).
|
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A novel
reaction of the coenzyme of glutamate decarboxylase with
L-serine-O-sulfate. Biochemistry, 21, 4377-4386 (1982).
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